During the early 2000s, both bands collaborated on the title track of the television sitcom, Jutt and Bond which featured both Khan and Butt.
His last TV serial was Ahson Talish's sociodrama Numm.
Broadcast in 2013, the drama saw Khan play a boy who secretly marries a girl in London and, after returning Pakistan, is forced to marry another girl.
Writing for The Indian Express, Ranika Rajani praised Humsafar saying, "The Pakistani drama is a breath of fresh air in comparison to its Indian counterparts." Writing about the performers she said, "The chemistry between Mahira Khan and Fawad Khan is also one of the reasons why Humsafar is a must watch.
Both of them convincingly wow you with their performance." Zee News's critic Ritka Handoo also praised the lead performances saying, "The lead pair, Fawad Khan and Mahira Khan, has struck just the right chord.
The family moved back to Lahore when he was aged 13.
Khan has two sisters, his elder sister Aliya is an architect by profession; while his younger sister, Sana, is a doctor.
He earned critical praise for his portrayal of a closet homosexual in Shakun Batra's Hindi family drama Kapoor & Sons (2016), which became a major critical and commercial success.
Khan appeared on Pepsi Battle of the Bands (2017) as a judge, which marked his return to music.
We as audiences have been finally gifted a new albeit quite believable on screen couple." The following year, he appeared in Sarmad Khoosat's TV series, Ashk which received a negative review from The Express Tribune critic.