She made her debut at the French Open where she fell to 22nd-seeded Francesca Schiavone in the second round.
In August, Vaidišová reached the quarterfinals at Toronto, losing to Justine Henin.
She reached the semifinal on her debut in Stanford, losing to Kim Clijsters.
At the US Open, Vaidišová made it to the third round, but lost to Jelena Janković, who later made it to the semifinal.
Vaidišová defeated Mauresmo for the second time at the Kremlin Cup, after rallying from 1–6, 2–5 down and three match points, in their quarterfinal match.
Vaidišová is an Australian Open and French Open semifinalist and also reached the quarterfinals at Wimbledon.
Vaidišová started playing tennis when she was six years old, enrolling to train at Nick Bollettieri's tennis academy in Bradenton, Florida. Her powerful groundstrokes, along with her serve, collaborated well together to produce an aggressive, all-round game. Her form dipped shortly after, and at the time her retirement was announced in 2010, she was ranked at No. Her stepfather announced that she had retired in March 2010, citing "lack of interest in tennis" as the primary reason, Vaidišová debuted in 2003 by reaching three consecutive finals: won $10K ITF/Plzeň-CZE, her only event in 2003, without dropping a set.
After her success in San Diego, Vaidišová moved from No.
12 to 9, her first career top 10 debut, becoming the 12th-youngest player in Tour history to crack the top 10, at an age of 17 years, three months and two weeks.47 and reached her first career Tier I quarterfinal at the Family Circle Cup.She posted her first top 10 victory over defending French Open champion Anastasia Myskina, before eventually losing to Patty Schnyder in the quarterfinals, and making her top 40 debut as a result at World No. In May, Vaidišová reached her first Tier III final in Istanbul, losing to top seed Venus Williams in the championship match.She followed by winning her second straight tour singles title in Tokyo, winning when Tatiana Golovin retired in the final.On 10 October, Vaidišová made her top 20 debut at World No.Vaidišová captured her sixth WTA title at the Tier III event in Strasbourg in May 2006.